Changing stimulation protocol on repeat conventional ovarian stimulation cycles does not lead to improved laboratory outcomes
نویسندگان
چکیده
ObjectiveTo evaluate whether physicians’ choice of ovarian stimulation protocol is associated with laboratory outcomes.DesignRetrospective cohort study.SettingSingle academic center.Patient(s)The subjects were 4,458 patients who completed more than one in vitro fertilization cycle within 1 year. On second stimulation, 49% repeated the same and 51% underwent a different one.Intervention(s)Estradiol priming antagonist, antagonist +/– oral contraceptive pill priming, long luteal protocol, Lupron (Lupron [AbbVie Inc, North Chicago, IL]) stop flare compared. Logistic or linear regression cluster robust standard errors to account for covariates paired data was used.Main Outcome Measure(s)Oocytes collected (OC), rate, blastocyst progression (BP), usable embryos (UE), euploid rate (ER).Result(s)First outcomes comparable across all protocols FR, BP, UE, ER but OC, after adjustment covariates. For effect switching differed according type stimulation. There improvement OC if repeated, except flare. In addition, there slight, significant improvements (difference values coefficient 0.02; 95% confidence interval [CI], 0.004, 0.4) UE (coefficient 1.25; CI, 0.79, 1.72) when repeated. no changes BP 0.03; –0.01, 0.08) 0.01; –0.04, 0.06) changed. low-BP subgroup, greater seen CI 0.01, 0.04).Conclusion(s)There slight so careful consideration should be made before purpose improving outcomes. To Retrospective study. Single center. The one. Estradiol used. Oocytes (ER). First 0.04).
منابع مشابه
comparison pregnancy outcomes between minimal stimulation protocol and conventional gnrh antagonist protocols in poor ovarian responders
objective: to compare the pregnancy outcomes achieved by in vitro fertilization (ivf) between minimal stimulation and conventional antagonist protocols in poor ovarian responders (pors). materials and methods: in this randomized controlled trial, 77 pors undergoing ivf were selected and divided into two groups. first group was the minimal stimulation group (n = 42) receiving 100 mg/day clomiphe...
متن کاملComparison Pregnancy Outcomes Between Minimal Stimulation Protocol and Conventional GnRH Antagonist Protocols in Poor Ovarian Responders
OBJECTIVE To compare the pregnancy outcomes achieved by in vitro fertilization (IVF) between minimal stimulation and conventional antagonist protocols in poor ovarian responders (PORs). MATERIALS AND METHODS In this randomized controlled trial, 77 PORs undergoing IVF were selected and divided into two groups. First group was the minimal stimulation group (n = 42) receiving 100 mg/day clomiphe...
متن کاملComparison of outcomes and direct cost between minimal stimulation and conventional protocols on ovarian stimulation in in vitro fertilization.
AIM To determine whether minimal stimulation with clomiphene and gonadotropin provides outcomes and direct costs comparable with those of a conventional GnRHa-gonadotropin stimulation protocol for infertile patients undergoing in vitro fertilization. METHODS A non-randomized clinical trial was conducted from 1 July 1996 to 31 March 2003 at the Infertility and Assisted Reproductive Unit, Ramat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2021
ISSN: ['0015-0282', '1556-5653']
DOI: https://doi.org/10.1016/j.fertnstert.2021.04.030